Methylcobalamin stimulates the methylation pathway which is responsible for:
- Making and repairing RNA and DNA, the genetic material responsible for every function in the body.
- Regulating parts of the immune system.
- Controls the detoxification of heavy metals and other harmful substances by making glutathione which is the body’s main detoxification pathway. Glutathione
- Is a major endogenous antioxidant made by cells to neutralize free radicals and reactive oxygen compounds having the ability to maintain vitamin E and vitamin C in their reduced form (active).
- Production and function of proteins, through the nitric acid pathway.
- Regulating iron metabolism.
- Cell cycle and cell death through controlling changes to nuclear proteins needed to differentiate cells.
Methylcobalamin (methyl B12) injections can enhance function in:
- Eye contact
- normalized behaviours and interaction
- Speech and language
- Spontaneous language
- More complex sentences
- Increased vocabulary
- Socialization with respect to understanding and expressing emotion
- Initiating plan have having more interactive play
- Understanding and feeling emotions
- Affection and tolerance to touch
Methylcobalamin (methyl B12) injections increase:
- Language, social, cognitive, improved behaviours
- Decrease hyperactivity
- Help sleep
- Increase stimming and sensory aggravation
- Increase mouthing of objects
- May stimulate diarrhea, constipation or ashes
- May initiate a period of aggression and irritability
Undesired effects to are a good sign of treatment success. They are not uncommon and include:
- Self-stimulating behaviour
- Increased mouthing of objects
- Sleep disturbances which can be managed with other treatments such as melatonin
- Aggression, hitting and biting
The seemingly negative side effects are caused by frustration when an increased awareness is present. Side effects can be mild to severe and are considered transient which means they will pass as treatment progresses.
Mechanism of Action of Methylcobalamin (methyl B12)
The methylation cycle metabolites and glutathione metabolism have been shown to be low in children on the Autism Spectrum Disorder (ASD). Altered methylation metabolism will result in a depletion of the precursors needed for glutathione production. Glutathione synthesis is connected to methylation metabolism. The methionine cycle involves the regeneration of methionine by the transfer to a methyl group from from 5-methyltetrahydrofolate (MTHF) to homocysteine in the methionine synthase reaction.
This system is methylcobalamin (B12) dependent.
Methionine is activated by methionine adenosyltransferase to form S-adenosylmethionine (SAM), the primary methyl donor for most cellular methytransferase reactions including the methylation of DNA, RNA, proteins, phospholipids, and neurotransmitters (brain chemicals).
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